Meng Kuang¹, Wei Xu¹, Chunxiang Cao¹, Lili Shen¹, Xunlei Zhang², Juan Chang³, Jinfei Chen¹, Tangcui Jun¹

¹Department of Oncology, Nanjing First Hospital, ²Department of Oncology, Nantong Tumor Hospital, ³Department of Oncology, Taixing people’s Hospital

Objective:Breast cancer (BC) is the most widespread cause of cancer-related death among women. Many published studies have assessed the association between Glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, whether GSTP1 rs1695 polymorphism could influence BC risk has been controversial. So we performed this meta-analysis to pursue a more comprehensive estimation of the association. Method: The electronic literature PUBMED was searched using the search terms: “rs1695”, “GSTP1”, “polymorphism” and “breast cancer” to look up all relevant articles. The search was limited to English language papers. Additionally, a hand search of references of original studies was used on this topic in order to identify additional studies. Studies which were satisfied to the following criteria were included in our meta-analysis: (a) performed a case–control studies, (b) contained available genotype frequencies for both patients and control populations or provided OR and 95% CI of relevant genetic models, (c) evaluation of the GSTP1 rs1695 polymorphism and breast cancer risk. Result: In total, 36 case–control trails including 20,615 cases and 20,481 controls were selected in our study. The primary features of these included studies are shown in Table1. Among these eligible publications, there were 21 studies from Europe, 12 from Asian and 2 from Africa and 3 of mixed people. There were ten studies of premenopausal women and 13 studies of postmenopausal women, While, 15 of them are hospital-based studies and 19 studies are population-based.Conclusion: In summary, our meta-analysis suggests that GSTP1 rs1695 A>G increase breast cancer risk in Asians. Understanding the components of CEMP molecular links may provide an avenue for preventive and therapeutic strategies to reduce cancer risk and mortality. Further investigations are needed to characterize the association of GSTP1 A>G polymorphism with breast cancer risk, and more original studies should be investigated to verify our result in the future.

Key Words: GSTP1  Polymorphism  Breast cancer