Dr Guo Fang

Director of Nano-medicine and translational medicinecenter, Shanghai Advanced Research Institute, Chinese Academy of Sciences.

Email: guofang@sibs.ac.cn

Research Area

• Molecular mechanisms of tumor invasion and metastasis

• Tumor-targeted drug development

• Tumor gene vaccine and cellular vaccine development

Research Project

• The mechanisms of Legumain actionin breast cancer metastasis.

• In the hypoxia and acidicmicroenvironment of solid tumors, the compound of Legumain and integrin couldactivate Pro-MMP2 and Pro-Cathepsin L to promote tumor growth, invasion andmetastasis. Legumain was taken as a target to develop targeted small moleculeanticancer compound and anti-cancer prodrugs.

• The role and mechanisms ofTumor-Associated Macrophages (TAMs) in promoting tumor metastasis and theimpact of Legumain on TAMs.

• Osteoclasts play an importantrole in bone metastases from cancer, whereas legumain may interacted with TRAF6from RANKL \ RANK \ TRAF6 that is differentiation spindle of osteoclast.

• Mouse models of Gelatin9KO(Lgals9), Mcl KO(Clec4d), Pomgnt1 KO(Pomgnt1) and DC-SIGN KO(Cd209a) weretaken to develop the impact of genes function on tumor growth and metastasis.